Astragalus is one of the commonly used Chinese herbal medicines. When used raw, it can help to strengthen the surface, diuretic and reduce swelling, and support toxins and promote muscle. Studies have shown that astragalus and its saponins have significant immune regulation, anti-inflammatory, antioxidant, anti-ischemic brain injury, anti-aging and nootropic effects. Astragalus saponins have been studied in depth at home and abroad, and dozens of astragalus saponins have been isolated and identified, such as acetyl astragaloside I, astragaloside I, II, astragaloside I-VIII, etc., astragaloside B, astragalus saponin I-XVI . Astragaloside IV (AstrChemicalbookagaloeideIV) A, also known as astragaloside IV, is an important saponin compound isolated from Astragalus with various pharmacological activities. It has a wide range of biological activities in the treatment of cardiovascular and cerebrovascular diseases, anti-aging, anti-inflammatory, analgesic, and immune regulation. However, the relative bioavailability of astragaloside in vivo is insufficient due to its relatively large relative molecular mass and inert solubility, which limits its development and promotion as a drug.
Astragaloside IV is a representative saponin component of traditional Chinese medicine Astragalus, and cycloastragenol is the sapogenin of astragaloside IV. Cycloastragaloside is the main hydrolyzed metabolite of astragaloside IV in the intestinal tract and absorbed into the blood component. It has a relatively small molecular mass and strong lipophilicity, which is conducive to biofilm penetration and gastrointestinal absorption to achieve better performance. bioavailability. A large number of modern medical studies have proved that astragaloside IV can reduce ischemia-reperfusion brain tissue damage by enhancing the body’s ability to scavenge oxygen free radicals, inhibiting peroxidation, and reducing neuronal calcium overload. The research of Geron Biotechnology Company of the United States found that CAG has a significant telomerase activation effect. RevGenetics of the United States also confirmed through research that CAG is one of the raw materials of functional cosmetics and nutritional foods, and is currently the only one that can be used in The raw material for activating telomerase in human cells is a promising anti-aging substance.
Application
1. Anti-aging: a telomerase activator that delays the shortening of telomeres by increasing telomerase and has an anti-aging effect. 2. Application in the preparation of anti-cancer adjuvant therapy drugs: the anti-cancer adjuvant therapy drug prepared by using it as the active chemical component of the drug can enhance the efficacy of anti-cancer drugs, reduce the toxicity of anti-cancer drugs, prevent and treat anti-cancer drug therapy Anticancer adjuvant therapy effect of induced leukopenia.