ASR-490 (CAS 2690312-67-3) is supplied by Monuo Chemical as a withaferin A–derived Notch1-pathway research compound for custom synthesis and cancer-biology R&D purchasing. Literature describes it as a picolinate (pyridine-2-carbonyl) analog of withaferin A. Buyers typically search by ASR-490, Notch1 inhibitor or CAS when sourcing a defined research reference.
Key Specifications at a Glance
| Product Name | ASR-490 (withaferin A pyridine-2-carbonyl / picolinate analog) |
|---|---|
| CAS Number | 2690312-67-3 |
| Molecular Formula | C34H41NO7 |
| Molecular Weight | 575.7 g/mol |
| Chemical Class | Withaferin A–derived ergostane δ-lactone / Notch1-pathway research small molecule |
| Typical Use Area | Oncology R&D reference; Notch1 signaling studies; colorectal / breast cancer cell-biology tool compound supply |
| Category | Custom synthesis |
| Documents | COA, TDS, SDS on request |
| Supply Origin | China | Worldwide shipping |
What Is ASR-490?
ASR-490 (CAS 2690312-67-3) is described in ChemicalBook and research catalogs as ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- (picolinate ester at C-4). Molecular formula C34H41NO7; molecular weight about 575.7 g/mol. Published syntheses start from withaferin A and use pyridine-2-carbonyl chloride to afford ASR-490 after chromatographic purification. Always match CAS 2690312-67-3 on the batch COA.
Molecular Cancer Therapeutics (2020) reports ASR-490 as a small molecule that binds the Notch1 negative regulatory region (NRR), downregulates Notch1 signaling and inhibits colorectal cancer cell growth in preclinical models. Subsequent peer-reviewed and meeting abstracts describe Notch1 modulation, breast cancer stem cell (BCSC) studies and chemosensitization research in triple-negative breast cancer (TNBC) cell systems. Research reagent suppliers list ASR-490 for laboratory use only. Monuo Chemical supplies ASR-490 as a specialty chemical raw material under Custom synthesis, with batch identity documentation (COA / SDS). It is not supplied as a finished drug product. Finished-product claims, labeling and local regulatory filings remain the customer’s responsibility.
Synonyms & Search Names
- ASR-490
- ASR490
- Withaferin A picolinate / pyridine-2-carbonyl analog
- Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-
- Notch1-pathway research compound (literature)
- CAS 2690312-67-3
Applications
In specialty chemical and custom synthesis projects, ASR-490 is commonly reviewed for:
- Notch1 signaling, NICD / HES1 / Hey-1 pathway studies in cancer cell lines
- Colorectal cancer (e.g., HCT116, SW620) and bladder / urothelial cell-biology assays cited in literature
- Breast cancer and BCSC / EMT research where Notch1 inhibition is evaluated
- Combination studies with chemotherapeutic agents in TNBC preclinical models (literature reports lower-dose combinations)
- SAR benchmarking alongside the thiophene analog ASR-488 (CAS 2690312-65-1) and other withaferin A derivatives
See related references in Custom synthesis.
Handling & Use Notes
- Assay check: Confirm purity (published syntheses report ≥98% by HPLC) on the batch COA before use.
- Dissolution: Prepare stock solutions in an appropriate research solvent (commonly DMSO in supplier protocols); verify solubility for your concentration and cell-assay format.
- Storage: Keep sealed at low temperature (−20 °C per research-supplier guidance); protect from moisture and light.
- Safety: For laboratory research only—not for human or veterinary administration. Follow the batch SDS for handling and disposal.
Need assay or packing discussion? Email [email protected] or use the contact form.
Packaging, Storage & Logistics
| Standard Pack Sizes | 50 g / 100 g bottles; 500 g / 1 kg packs (custom packing available) |
|---|---|
| Storage | Keep sealed, dry and cold (−20 °C). Follow the batch COA and SDS |
| Shelf Life | Confirm shelf life on the COA for each lot |
| MOQ | Commercial MOQ discussed per project (often from 50 g); smaller research packs available on request |
| Lead Time | Stock items often ship promptly; custom pack / large lots typically 7–14 working days |
Quality & Documentation
For ASR-490 (CAS 2690312-67-3), Monuo Chemical can provide:
- Certificate of Analysis (COA)
- Technical Data Sheet (TDS) and Safety Data Sheet (SDS)
- CAS / product-name confirmation for your purchase file
- Flexible packing from grams to kilograms
- FOB / CIF / DAP terms as agreed
Our team aims to return technical data and quotations within 24 hours.
Request a Quote
Share your target assay, pack size and destination. We will confirm availability and documentation for ASR-490 CAS 2690312-67-3.
Request a Quote | Email: [email protected]
Frequently Asked Questions
What is ASR-490 (CAS 2690312-67-3)?
ASR-490 is a withaferin A–derived research small molecule supplied under Custom synthesis. Confirm CAS 2690312-67-3 on the batch COA.
Why is ASR-490 described as a Notch1 inhibitor?
Molecular Cancer Therapeutics (2020) and follow-on studies report binding to the Notch1 NRR domain, downregulation of Notch1 signaling and reduced viability in several cancer cell models. Monuo Chemical supplies the compound for R&D reference; no therapeutic efficacy is claimed on this page.
How is ASR-490 synthesized?
Literature routes describe reaction of withaferin A with pyridine-2-carbonyl chloride in dichloromethane with triethylamine, followed by extractive work-up and silica-gel chromatography. Characterization is by NMR and MS with HPLC purity ≥98% in published batches.
Is ASR-490 the same as ASR-488?
No. ASR-490 (CAS 2690312-67-3; C34H41NO7) bears a pyridine-2-carbonyl (picolinate) group and is studied mainly in Notch1 contexts. ASR-488 (CAS 2690312-65-1) is the thiophene-2-carbonyl analog reported in CPEB1/apoptosis research.
Which cell models appear in published work?
Literature cites colorectal lines (e.g., HCT116, SW620), bladder / urothelial lines and triple-negative breast cancer models in Notch1 and chemosensitization studies. Verify fit for your protocol before ordering.
Is this product a plant extract?
No. ASR-490 is a semi-synthetic withaferin A analog correctly categorized under Custom synthesis.
What purity should I expect?
Published syntheses target ≥98% HPLC. Exact assay and impurity profile are stated on the Certificate of Analysis for each Monuo Chemical lot.
Where can I find related research compounds?
Review Timonacic (CAS 444-27-9), 1,3-Diacetyl-2-imidazolidinone (CAS 5391-40-2), or the full Custom synthesis catalog.
Related Products
- ASR-488 (CAS 2690312-65-1)
- Timonacic (CAS 444-27-9)
- 25-Desacetylrifapentine (CAS 79039-56-8)
- View all Custom synthesis
Disclaimer: Information is for specialty chemical raw-material identification and technical reference. ASR-490 is supplied for laboratory research use as described on the COA—not as a finished pharmaceutical, diagnostic or consumer product. Published biology is cited for R&D context only. Finished-product claims and regulatory filings remain the customer’s responsibility. Verify each lot against the supplied COA and SDS. Trade terms are FOB / CIF / DAP as agreed.
