ASR-488 (CAS 2690312-65-1) is supplied by Monuo Chemical as a withaferin A–derived ergostane lactone research compound for custom synthesis and oncology R&D purchasing. Literature and supplier catalogs also reference the systematic name for this CPEB1-modulating small molecule. Buyers typically search by ASR-488, withaferin A analog or CAS when sourcing a defined research reference.
Key Specifications at a Glance
| Product Name | ASR-488 (withaferin A thiophene-2-carbonyl analog) |
|---|---|
| CAS Number | 2690312-65-1 |
| Molecular Formula | C33H40O7S |
| Molecular Weight | 580.73 g/mol |
| Chemical Class | Withaferin A–derived ergostane δ-lactone / research small molecule |
| Typical Use Area | Oncology R&D reference; CPEB1 / apoptosis pathway studies; cell-biology tool compound supply |
| Category | Custom synthesis |
| Documents | COA, TDS, SDS on request |
| Supply Origin | China | Worldwide shipping |
What Is ASR-488?
ASR-488 (CAS 2690312-65-1) is described in ChemicalBook and research-supplier catalogs as ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-thienylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-. Molecular formula C33H40O7S; molecular weight about 580.73 g/mol. Published synthesis routes start from withaferin A and introduce a thiophene-2-carbonyl protecting group at the C-4 hydroxy position. Always match CAS 2690312-65-1 on the batch COA.
Peer-reviewed literature (Oncology Letters, 2020) reports that ASR-488 activates the mRNA-binding protein CPEB1, induces apoptosis and inhibits bladder cancer cell proliferation in preclinical cell models, with reduced toxicity toward normal bladder cells in those studies. Research reagent suppliers position ASR-488 strictly for laboratory research—not as a finished drug or consumer product. Monuo Chemical supplies ASR-488 as a specialty chemical raw material under Custom synthesis, with batch identity documentation (COA / SDS). Finished-product claims, labeling and local regulatory filings remain the customer’s responsibility. Confirm structure and assay against the batch COA for your intended method.
Synonyms & Search Names
- ASR-488
- ASR488
- Withaferin A thiophene-2-carbonyl analog
- Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-thienylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-
- CPEB1-modulating withaferin A derivative (research literature)
- CAS 2690312-65-1
Applications
In specialty chemical and custom synthesis projects, ASR-488 is commonly reviewed for:
- Cell-biology and oncology R&D where CPEB1 activation and apoptosis pathways are studied
- Bladder cancer cell-line proliferation and viability assays cited in published preclinical work
- Structure–activity relationship (SAR) studies alongside other withaferin A–derived analogs such as ASR-490
- Catalog purchasing of CAS-matched research small molecules for defined laboratory workflows
- Method development requiring a characterized withaferin A acyl derivative reference compound
Compare the related Notch1-pathway analog ASR-490 (CAS 2690312-67-3) and other items in Custom synthesis.
Handling & Use Notes
- Assay check: Confirm purity (literature syntheses report ≥98% by HPLC) on the batch COA before use.
- Dissolution: Research suppliers note good solubility in DMSO; sonication may be required for stock-solution preparation—verify against your protocol and the batch TDS.
- Storage: Store sealed at low temperature (research catalogs commonly recommend −20 °C); protect from moisture and unnecessary light.
- Safety: Handle as a research compound only. Follow the SDS for PPE, storage and waste disposal. This material is not supplied for human or veterinary use.
Need assay or packing discussion? Email [email protected] or use the contact form.
Packaging, Storage & Logistics
| Standard Pack Sizes | 50 g / 100 g bottles; 500 g / 1 kg packs (custom packing available) |
|---|---|
| Storage | Keep sealed, dry and cold (−20 °C per research-supplier guidance). Follow the batch COA and SDS |
| Shelf Life | Confirm shelf life on the COA for each lot |
| MOQ | Commercial MOQ discussed per project (often from 50 g); smaller research packs available on request |
| Lead Time | Stock items often ship promptly; custom pack / large lots typically 7–14 working days |
Quality & Documentation
For ASR-488 (CAS 2690312-65-1), Monuo Chemical can provide:
- Certificate of Analysis (COA)
- Technical Data Sheet (TDS) and Safety Data Sheet (SDS)
- CAS / product-name confirmation for your purchase file
- Flexible packing from grams to kilograms
- FOB / CIF / DAP terms as agreed
Our team aims to return technical data and quotations within 24 hours. See also Custom synthesis.
Request a Quote
Share your target assay, pack size and destination. We will confirm availability and documentation for ASR-488 CAS 2690312-65-1.
Request a Quote | Email: [email protected]
Frequently Asked Questions
What is ASR-488 (CAS 2690312-65-1)?
ASR-488 is a withaferin A–derived ergostane lactone research compound listed by Monuo Chemical under Custom synthesis. Match CAS 2690312-65-1 on the batch COA.
How is ASR-488 related to withaferin A?
Published synthesis describes acylation of withaferin A with 2-thiophenecarbonyl chloride to introduce a thiophene-2-carbonyl group at the C-4 hydroxy position, yielding ASR-488 as a defined structural analog for SAR and cell-biology studies.
What does the research literature report for ASR-488?
Oncology Letters (2020) reports CPEB1 activation, apoptosis induction and inhibition of bladder cancer cell growth in preclinical models. Monuo Chemical supplies the compound as a research raw material; therapeutic claims are not made here.
Is ASR-488 a plant extract?
No. Although derived from a withaferin A scaffold, ASR-488 is a semi-synthetic research small molecule and belongs under Custom synthesis, not botanical extract catalogs.
How does ASR-488 differ from ASR-490?
ASR-488 carries a thiophene-2-carbonyl substituent (C33H40O7S) and is studied in CPEB1/apoptosis contexts. The pyridine-2-carbonyl analog ASR-490 (CAS 2690312-67-3) is reported as a Notch1-pathway inhibitor in separate literature.
What are typical storage conditions?
Research suppliers recommend −20 °C, sealed and protected from moisture and light. Use the batch SDS as the controlling document.
What documents can Monuo Chemical provide?
COA, TDS and SDS are standard. Specify CAS 2690312-65-1 and ASR-488 on your quote request.
Which related Custom synthesis products can I review?
See 25-Desacetylrifapentine (CAS 79039-56-8), Novobiocin sodium (CAS 1476-53-5), or browse all Custom synthesis products.
Related Products
- ASR-490 (CAS 2690312-67-3)
- 25-Desacetylrifapentine (CAS 79039-56-8)
- Novobiocin sodium (CAS 1476-53-5)
- View all Custom synthesis
Disclaimer: Information is for specialty chemical raw-material identification and technical reference. ASR-488 is supplied for laboratory research use as described on the COA—not as a finished pharmaceutical, diagnostic or consumer product. Published biology is cited for R&D context only. Finished-product claims and regulatory filings remain the customer’s responsibility. Verify each lot against the supplied COA and SDS. Trade terms are FOB / CIF / DAP as agreed.
