ASR-488 (CAS 2690312-65-1) is supplied by Monuo Chemical as a withaferin A–derived ergostane lactone research compound for custom synthesis and oncology R&D purchasing. Literature and supplier catalogs also reference the systematic name for this CPEB1-modulating small molecule. Buyers typically search by ASR-488, withaferin A analog or CAS when sourcing a defined research reference.
Key Specifications at a Glance
| Product Name | ASR-488 (withaferin A thiophene-2-carbonyl analog) |
|---|---|
| CAS Number | 2690312-65-1 |
| Molecular Formula | C33H40O7S |
| Molecular Weight | 580.73 g/mol |
| Chemical Class | Withaferin A–derived ergostane δ-lactone / research small molecule |
| Typical Use Area | Oncology R&D reference; CPEB1 / apoptosis pathway studies; cell-biology tool compound supply |
| Category | Custom synthesis |
| Documents | COA and SDS available on request |
| Supply Origin | China | Worldwide shipping |
What Is ASR-488?
ASR-488 (CAS 2690312-65-1) is described in ChemicalBook and research-supplier catalogs as ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-thienylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-. Molecular formula C33H40O7S; molecular weight about 580.73 g/mol. Published synthesis routes start from withaferin A and introduce a thiophene-2-carbonyl protecting group at the C-4 hydroxy position. Always match CAS 2690312-65-1 on the batch COA.
Peer-reviewed literature (Oncology Letters, 2020) reports that ASR-488 activates the mRNA-binding protein CPEB1, induces apoptosis and inhibits bladder cancer cell proliferation in preclinical cell models, with reduced toxicity toward normal bladder cells in those studies. Research reagent suppliers position ASR-488 strictly for laboratory research—not as a finished drug or consumer product. Monuo Chemical supplies ASR-488 as a specialty chemical raw material under Custom synthesis, with batch identity documentation (COA / SDS). Finished-product claims, labeling and local regulatory filings remain the customer’s responsibility. Confirm structure and assay against the batch COA for your intended method.
Synonyms & Search Names
- ASR-488
- ASR488
- Withaferin A thiophene-2-carbonyl analog
- Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-thienylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-
- CPEB1-modulating withaferin A derivative (research literature)
- CAS 2690312-65-1
Applications
In specialty chemical and custom synthesis projects, ASR-488 is commonly reviewed for:
- Cell-biology and oncology R&D where CPEB1 activation and apoptosis pathways are studied
- Bladder cancer cell-line proliferation and viability assays cited in published preclinical work
- Structure–activity relationship (SAR) studies alongside other withaferin A–derived analogs such as ASR-490
- Catalog purchasing of CAS-matched research small molecules for defined laboratory workflows
- Method development requiring a characterized withaferin A acyl derivative reference compound
Compare the related Notch1-pathway analog ASR-490 (CAS 2690312-67-3) and other items in Custom synthesis.
Handling & Use Notes
- Assay check: Confirm purity (literature syntheses report ≥98% by HPLC) on the batch COA before use.
- Dissolution: Research suppliers note good solubility in DMSO; sonication may be required for stock-solution preparation—verify against your protocol and the batch TDS.
- Storage: Store sealed at low temperature (research catalogs commonly recommend −20 °C); protect from moisture and unnecessary light.
- Safety: Handle as a research compound only. Follow the SDS for PPE, storage and waste disposal. This material is not supplied for human or veterinary use.
Need assay or packing discussion? Email [email protected] or use the contact form.
Packaging, Storage & Logistics
| Standard Pack Sizes | 50 g / 100 g bottles; 500 g / 1 kg packs (custom packing available) |
|---|---|
| Storage | Keep sealed, dry and cold (−20 °C per research-supplier guidance). Follow the batch COA and SDS |
| Shelf Life | Confirm shelf life on the COA for each lot |
| MOQ | Discussed per project. Paid evaluation quantities are available on quotation (not free). |
| Lead Time | Confirmed after stock availability, packing, and shipping terms are agreed |
Quality & Documentation
For ASR-488 (CAS 2690312-65-1), Monuo Chemical can provide:
- Certificate of Analysis (COA)
- Technical Data Sheet (TDS) and Safety Data Sheet (SDS)
- CAS / product-name confirmation for your purchase file
- Flexible packing from grams to kilograms
- FOB / CIF / DAP terms as agreed
Our team aims to return technical data and quotations within 24 hours. See also Custom synthesis.
Request a Quote
Share your target assay, pack size and destination. We will confirm availability and documentation for ASR-488 CAS 2690312-65-1.
Request a Quote | Email: [email protected]
Frequently Asked Questions
What is ASR-488 (CAS 2690312-65-1)?
ASR-488 is a withaferin A–derived ergostane lactone research compound listed by Monuo Chemical under Custom synthesis. Match CAS 2690312-65-1 on the batch COA.
How is ASR-488 related to withaferin A?
Published synthesis describes acylation of withaferin A with 2-thiophenecarbonyl chloride to introduce a thiophene-2-carbonyl group at the C-4 hydroxy position, yielding ASR-488 as a defined structural analog for SAR and cell-biology studies.
What does the research literature report for ASR-488?
Oncology Letters (2020) reports CPEB1 activation, apoptosis induction and inhibition of bladder cancer cell growth in preclinical models. Monuo Chemical supplies the compound as a research raw material; therapeutic claims are not made here.
Is ASR-488 a plant extract?
No. Although derived from a withaferin A scaffold, ASR-488 is a semi-synthetic research small molecule and belongs under Custom synthesis, not botanical extract catalogs.
How does ASR-488 differ from ASR-490?
ASR-488 carries a thiophene-2-carbonyl substituent (C33H40O7S) and is studied in CPEB1/apoptosis contexts. The pyridine-2-carbonyl analog ASR-490 (CAS 2690312-67-3) is reported as a Notch1-pathway inhibitor in separate literature.
What are typical storage conditions?
Research suppliers recommend −20 °C, sealed and protected from moisture and light. Use the batch SDS as the controlling document.
What documents can Monuo Chemical provide?
COA and SDS are available on request. Additional project documents can be discussed when needed.
Which related Custom synthesis products can I review?
See 25-Desacetylrifapentine (CAS 79039-56-8), Novobiocin sodium (CAS 1476-53-5), or browse all Custom synthesis products.
Related Products
- ASR-490 (CAS 2690312-67-3)
- 25-Desacetylrifapentine (CAS 79039-56-8)
- Novobiocin sodium (CAS 1476-53-5)
- View all Custom synthesis
Disclaimer: Information is for specialty chemical raw-material identification and technical reference. ASR-488 is supplied for laboratory research use as described on the COA—not as a finished pharmaceutical, diagnostic or consumer product. Published biology is cited for R&D context only. Finished-product claims and regulatory filings remain the customer’s responsibility. Verify each lot against the supplied COA and SDS. Trade terms are FOB / CIF / DAP as agreed.
