CAS No. 14605-22-2 Tauroursodeoxycholic Acid

Tauroursodeoxycholic Acid (TUDCA) is a highly hydrophilic tertiary bile acid, the taurine conjugate of ursodeoxycholic acid. Naturally occurring in humans and bear bile, it is widely used in biomedical research for its anti-apoptotic, ER stress-inhibiting, and neuroprotective properties. Applications include Alzheimer's, Huntington's, liver disease, and stroke research. Available in research grade through high-purity pharmaceutical grade.

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Category Property Specification Note
Basic Info Product Name Tauroursodeoxycholic Acid (TUDCA)
CAS Number 14605-22-2 Synonyms: Ursodoxicoltaurine
Molecular Formula / MW C₂₆H₄₅NO₆S / 499.71 g/mol
Physical Appearance & State White solid (crystalline powder)
Purity / Active Content ≥ 98% (HPLC) — Research Grade; ≥ 95% (Standard) Highest: ≥ 99%
Melting / Boiling Point 173-175 °C / N/A
Density / Refractive Index 1.216 g/cm³ / [α] = +46° (c=1, EtOH)
Solubility DMSO (up to 30 mg/mL), Ethanol (up to 20 mg/mL with warming) pKa: 1.42
Technical Grade / Function Biochemical Reagent / Bile Acid / Apoptosis Inhibitor
Applications ER stress & apoptosis research, Neuroprotection (Alzheimer’s, Huntington’s, Stroke), Liver disease research, Myocardial infarction, Protein misfolding studies
Safety GHS Classification Safety: S22-24/25 (Do not breathe dust, avoid skin/eye contact)
HS Code 2924.29 (Cyclic amides)
Logistics Standard Packaging 50 g / 100 g Fluoride bottle; 500 g / 1 kg fiber drum
Storage Conditions 15-25°C (room temperature). DMSO/EtOH solutions: -20°C up to 1 month. Protect from moisture.
Shelf Life 24 months (2 years) under recommended storage

Frequently Asked Questions

Category Question Short Answer
Basic Info What is Tauroursodeoxycholic Acid (TUDCA) CAS 14605-22-2? A hydrophilic bile acid — the taurine conjugate of ursodeoxycholic acid. Used in research for apoptosis, ER stress, and neuroprotection studies.
Basic Info What is the molecular formula? C₂₆H₄₅NO₆S, MW 499.71 g/mol. A taurine-conjugated bile acid naturally found in humans and bear bile.
Application What research fields use TUDCA? Neurodegenerative disease research (Alzheimer’s, Huntington’s), liver disease, stroke, myocardial infarction, and protein misfolding/ER stress studies.
Application Is TUDCA used for ER stress research? Yes. TUDCA is a well-known chemical chaperone that inhibits ER stress by activating PERK and reducing protein synthesis, halting misfolded protein aggregation.
Performance What purity levels are available? Standard ≥95%, Research ≥98% (HPLC), Pharma ≥99%. All with Certificate of Analysis (CoA).
Performance How stable is TUDCA? Stable for 24 months at 15-25°C. DMSO/EtOH solutions stable up to 1 month at -20°C.
Storage How should TUDCA be stored? 15-25°C, dry, sealed container. Solutions in DMSO/ethanol at -20°C for up to 1 month. Protect from moisture.
Storage How is TUDCA packaged? 50 g / 100 g Fluoride bottles; 500 g / 1 kg fiber drums. Custom packaging available.

 

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