Repotrectinib (CAS 1802220-02-5) is supplied by Monuo Chemical for specialty chemical and custom synthesis purchasing. It is also referenced as TPX-0005 and Ropotrectinib. Buyers typically search by product name or CAS when sourcing next-generation ROS1 / TRK / ALK tyrosine kinase inhibitor biochemicals for oncology research.
Key Specifications at a Glance
| Product Name | Repotrectinib |
|---|---|
| CAS Number | 1802220-02-5 |
| Molecular Formula | C18H18FN5O2 |
| Molecular Weight | 355.37 g/mol |
| Chemical Class | Macrocyclic tyrosine kinase inhibitor / specialty biochemical |
| Typical Use Area | Oncology / biochemical R&D; ROS1, TRK and ALK pathway studies |
| Category | Custom synthesis |
| Documents | COA, TDS, SDS on request |
| Supply Origin | China | Worldwide shipping |
What Is Repotrectinib?
Repotrectinib (CAS 1802220-02-5), also known as TPX-0005, is a compact macrocyclic tyrosine kinase inhibitor designed to target ROS1, TRK (NTRK) and ALK fusions, including selected solvent-front and other resistance mutations. Molecular formula C18H18FN5O2; molecular weight about 355.37 g/mol. Always match CAS 1802220-02-5 on the batch COA.
In laboratory literature it is described as a potent inhibitor of wild-type ROS1, TRKA–C and ALK kinase activity (reported IC50 values often in the low-nanomolar range), with research interest in ROS1-positive NSCLC models and CNS-penetration related pathway studies. Monuo Chemical supplies Repotrectinib as a specialty chemical raw material under Custom synthesis, with batch identity documentation (COA / SDS). Finished-product claims, labeling and local regulatory filings remain the brand manufacturer’s responsibility. Confirm grade and assay against the batch COA for your intended method.
Synonyms & Search Names
- Repotrectinib
- TPX-0005 / TPX 0005 / TPX0005
- Ropotrectinib
- (7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one
- CAS 1802220-02-5
Applications
In specialty biochemical and oncology R&D projects, Repotrectinib is commonly reviewed for:
- ROS1 fusion / ROS1 tyrosine kinase inhibition studies, including solvent-front mutation models (e.g. G2032R-related research contexts)
- Pan-TRK (TRKA–C / NTRK) and ALK pathway inhibitor screening
- Next-generation TKI mechanism and resistance-mutation probe work in cell-biology model systems
- Catalog purchasing for custom synthesis of specialty macrocyclic kinase-inhibitor biochemicals
Compare related specialty items such as Novobiocin sodium (CAS 1476-53-5) in the same Custom synthesis range.
Handling & Use Notes
- Assay check: Confirm specification / assay for Repotrectinib on the batch COA before use.
- Container handling: Keep sealed and dry; protect from unnecessary light and heat during sampling.
- Process fit: Verify solubility and stability in your intended solvent / media system (DMSO is commonly cited in research catalogs) before scale-up.
- Safety: Follow the SDS for storage, PPE and waste handling. Use the batch SDS as the controlling safety document.
Need assay or packing discussion? Email [email protected] or use the contact form.
Packaging, Storage & Logistics
| Standard Pack Sizes | 50 g / 100 g bottles; 500 g / 1 kg packs (custom packing available) |
|---|---|
| Storage | Keep sealed, dry and protected from light and heat. Follow the batch COA and SDS |
| Shelf Life | Confirm shelf life on the COA for each lot |
| MOQ | Commercial MOQ discussed per project (often from 50 g); larger packs available on request |
| Lead Time | Stock items often ship promptly; custom pack / large lots typically 7–14 working days |
Quality & Documentation
For Repotrectinib (CAS 1802220-02-5), Monuo Chemical can provide:
- Certificate of Analysis (COA)
- Technical Data Sheet (TDS) and Safety Data Sheet (SDS)
- CAS / product-name confirmation for your purchase file
- Flexible packing from grams to kilograms
- FOB / CIF / DAP terms as agreed
Our team aims to return technical data and quotations within 24 hours. See also Custom synthesis.
Request a Quote
Share your target assay, pack size and destination. We will confirm availability and documentation for Repotrectinib CAS 1802220-02-5.
Request a Quote | Email: [email protected]
Frequently Asked Questions
What is Repotrectinib (CAS 1802220-02-5)?
It is a macrocyclic tyrosine kinase inhibitor biochemical, also known as TPX-0005, targeting ROS1, TRK and ALK pathways in research models. Monuo Chemical lists it under Custom synthesis. Match CAS 1802220-02-5 on the batch COA.
Is TPX-0005 the same material?
Yes. TPX-0005 is the common research / development code for Repotrectinib. Always put CAS 1802220-02-5 on RFQs and POs.
What is the molecular formula and weight?
Listed values are molecular formula C18H18FN5O2; molecular weight about 355.37 g/mol. Confirm on the batch COA/TDS.
Where is Repotrectinib typically used in R&D?
Typical laboratory uses include ROS1 / TRK / ALK kinase inhibition studies and resistance-mutation related oncology model research. Monuo supplies raw-material identity documentation only; finished-product claims remain the customer’s responsibility.
What specification do you supply?
Exact assay and grade are confirmed on the Certificate of Analysis for each lot. Share your target specification when you request a quote.
How should Repotrectinib be stored?
Keep sealed, dry and protected from unnecessary light and heat. Follow the batch SDS and COA for controlling storage conditions.
How do I request a quotation for CAS 1802220-02-5?
Share target assay, pack size and destination via the Request a Quote page or email [email protected]. We aim to reply within 24 hours.
Which related Custom synthesis products can I review?
You may also review Novobiocin sodium (CAS 1476-53-5) and 1H-Pyrazole-1-carboxamidine hydrochloride (CAS 4023-02-3), or open the full Custom synthesis catalog.
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Disclaimer: Information is for specialty chemical raw-material identification and technical reference. Finished-product claims and regulatory filings remain the customer’s responsibility. Verify each lot against the supplied COA and SDS. Trade terms are FOB / CIF / DAP as agreed.
