| Category | Property | Specification |
| Basic Info | Product Name | Sodium Taurodeoxycholate (Taurodeoxycholic acid sodium salt) |
| CAS Number | 1180-95-6 | |
| Molecular Formula / MW | C₂₆H₄₄NNaO₆S / 521.69 g/mol | |
| Appearance & State | White to off-white crystalline powder | |
| Purity / Active Content | ≥ 98% (HPLC) — Research Grade; ≥ 95% (Food/Pharma Grade available) | |
| Melting / Boiling Point | 168 °C (dec.) / N/A | |
| Density / Bulk Density | N/A (crystalline powder) | |
| Solubility | H₂O: 0.5 M at 20°C (clear, colorless to faintly yellow); soluble in water; pKa 1.9 | |
| Grade / Function | Biochemical Reagent / Anionic Detergent / Bile Salt / Pharmaceutical Intermediate | |
| Applications | Biochemical research (membrane protein isolation), Pharmaceutical (liver/gallbladder disorders, anticancer research), Cosmetics (skin detoxification), Bile acid metabolism studies, Detergent for mitochondrial membrane proteins | |
| Safety | GHS Classification | Warning (GHS07). H315: Skin irritation; H319: Eye irritation; H335: Respiratory irritation. Precaution: P264-P280-P302+P352-P305+P351+P338 |
| HS Code | 2924.29 (Cyclic amides — bile acids and derivatives) | |
| Logistics | Standard Packaging | 25 g / 100 g / 500 g HDPE bottle; 1 kg / 5 kg / 25 kg fiber drum with PE liner |
| Storage Conditions | Keep in dark place, inert atmosphere, room temperature (or freezer -20°C for long-term). Keep container tightly sealed. Avoid moisture and light. | |
| Shelf Life | 24 months (2 years) under recommended storage conditions |
Frequently Asked Questions
| Category | Question | Short Answer |
| Basic Info | What is Sodium Taurodeoxycholate (CAS 1180-95-6)? | Sodium Taurodeoxycholate (STDC) is a bile salt derivative — the sodium salt of taurodeoxycholic acid. It is a white crystalline powder used as an anionic detergent and biochemical reagent. |
| Basic Info | What is the molecular formula of Sodium Taurodeoxycholate? | C₂₆H₄₄NNaO₆S, molecular weight 521.69 g/mol. It is a taurine-conjugated bile acid (deoxycholic acid + taurine). |
| Application | What research and industries use Sodium Taurodeoxycholate? | Biochemical & pharmaceutical research (membrane protein isolation, bile acid metabolism), pharmaceutical industry (liver/gallbladder therapeutics), and cosmetics (skin barrier function). |
| Application | Can Sodium Taurodeoxycholate be used for membrane protein isolation? | Yes. STDC is a well-established anionic detergent used for solubilization of membrane-bound proteins, including inner mitochondrial membrane proteins, forming mixed micelles. |
| Performance | What purity levels of Sodium Taurodeoxycholate are available? | Standard: ≥ 95% (HPLC). High-purity research grade: ≥ 97% (HPLC). Pharma grade: ≥ 98%. All with Certificate of Analysis. |
| Performance | What is the optical rotation and pKa of Sodium Taurodeoxycholate? | Optical rotation: [α] = +33° (c=3, water). pKa: 1.9 (sulfonic acid group, strongly acidic). |
| Storage & Transport | How should Sodium Taurodeoxycholate be stored? | Store in a dark place under an inert atmosphere at room temperature or -20°C for long-term. Keep sealed and dry. Shelf life: 24 months. |
| Storage & Transport | How is Sodium Taurodeoxycholate packaged for export? | Standard: 25 g / 100 g / 500 g HDPE bottles; 1 kg / 5 kg / 25 kg fiber drums. Custom packaging available upon request. |
| Compliance & Safety | Is Sodium Taurodeoxycholate hazardous? | GHS07 — Warning. Causes skin (H315) and eye (H319) irritation, respiratory irritation (H335). Use PPE: gloves, safety goggles. Non-flammable, non-explosive. |
| Procurement | What is the MOQ for Sodium Taurodeoxycholate? | Standard MOQ: 25 g for research, 1 kg for bulk. Samples (5–25 g) available for evaluation. Lead time: 7–15 working days. FOB/CIF/DDP terms. |
Detailed FAQ (Full Version — Suitable for Dedicated FAQ Page)
| Category | FAQ Question | Detailed Answer |
| Basic Properties | 1. What is Sodium Taurodeoxycholate and what is its CAS number? | Sodium Taurodeoxycholate (CAS 1180-95-6), also known as STDC, Taurodeoxycholic acid sodium salt, or Sodium deoxytaurocholate, is a bile salt derivative and anionic detergent. It is the sodium salt of taurodeoxycholic acid — a taurine-conjugated form of deoxycholic acid. Its molecular formula is C₂₆H₄₄NNaO₆S (MW 521.69 g/mol). Naturally occurring in the human body, it plays a key role in fat digestion and absorption. In biochemical research, it is widely used as a detergent for solubilizing membrane-bound proteins, including inner mitochondrial membrane proteins, and as a tool for studying bile acid metabolism and signaling pathways. |
| Basic Properties | 2. What are the key physical and chemical properties of Sodium Taurodeoxycholate? | Key physicochemical properties include: • Appearance: White to off-white crystalline powder • Purity: ≥ 97% (HPLC research grade); ≥ 95% (standard grade) • Molecular Formula: C₂₆H₄₄NNaO₆S / MW: 521.69 g/mol • EINECS Number: 214-652-0 • Melting Point: 168 °C (decomposition) • Optical Rotation: [α] = +33° (c=3, water) • pKa: 1.9 (sulfonic acid group) • Solubility: Soluble in water (0.5 M at 20°C, clear solution) • Form: Solid (crystalline) • Hygroscopic: Moderately hygroscopic — store in sealed, dry conditions • Detergent Type: Anionic bile salt detergent — forms mixed micelles |
| Applications | 3. What are the main applications and uses of Sodium Taurodeoxycholate? | Sodium Taurodeoxycholate serves multiple roles across research and industry: • Biochemical Research: Solubilization and isolation of membrane-bound proteins (including inner mitochondrial membrane proteins), membrane protein crystallization, and reconstitution studies • Pharmaceutical Research: Bile acid metabolism studies, liver/gallbladder disease research, anticancer research (colon cancer — activates EGFR-dependent PI3K/Akt signaling), Huntington’s disease neuroprotection studies • In Vivo Studies: Ameliorates DSS-induced colitis in mice (1.25–5 mg/kg, p.o.); reduces striatal neuropathology in Huntington’s disease models (50 mg/kg, i.p.); protects against sepsis (0.5 mg/kg, i.v.) • Cosmetics: Skin barrier function enhancement, natural detoxification support • Drug Delivery: Bile acid-based drug delivery systems and micellar formulations |
| Applications | 4. How does Sodium Taurodeoxycholate compare to other bile salts (e.g., sodium cholate, sodium deoxycholate)? | Compared to sodium cholate: STDC has stronger detergent properties (more hydrophobic due to dihydroxy vs trihydroxy structure), better membrane protein solubilization efficiency. Compared to sodium deoxycholate: STDC is the taurine-conjugated form — more water-soluble, less prone to precipitation at low pH, and biologically more relevant as a natural conjugated bile salt. Compared to CHAPS/CHAPSO: STDC is naturally derived, less expensive, but has stronger denaturing potential — preferred for integral membrane protein extraction over structural studies. Critical Micelle Concentration (CMC): Lower CMC than sodium cholate, making it more effective at lower concentrations for membrane solubilization. |
| Performance | 5. What purity levels and grades of Sodium Taurodeoxycholate are commercially available? | We offer Sodium Taurodeoxycholate in multiple grades: • Standard Grade (≥ 95%): Suitable for general biochemical use and cosmetic applications • Research Grade (≥ 97% HPLC): For membrane protein studies and cell biology research • High-Purity Grade (≥ 98%): For pharmaceutical research and sensitive assays • Pharmaceutical/API Grade (≥ 99%): For drug development and clinical research • Cell Culture Tested: Sterile-filtered, endotoxin-tested for cell-based assays Each batch ships with Certificate of Analysis (CoA) with HPLC purity, optical rotation, and solubility data. |
| Performance | 6. How stable is Sodium Taurodeoxycholate under different conditions? | STDC shows good stability under standard handling conditions: • Thermal Stability: Stable at room temperature; decomposes at 168°C • Solution Stability: Aqueous solutions (0.5 M) clear and colorless to faintly yellow at 20°C • pH Stability: Stable in neutral to slightly alkaline pH; may precipitate in strong acid • Light Sensitivity: Light-sensitive — store in dark container • Oxidative Stability: Store under inert atmosphere (N₂/Ar) for long-term storage • Long-term Storage: 24 months at room temperature; ≥36 months at -20°C • Hydrolytic Stability: Resistant to hydrolysis at neutral pH in aqueous solutions |
| Storage & Transport | 7. What are the proper storage, handling, and shipping guidelines for Sodium Taurodeoxycholate? | To maintain product quality and safety: • Storage: Store in dark place, inert atmosphere, at room temperature (15–25°C) or freezer (-20°C) for extended periods • Container: Keep in tightly sealed HDPE bottle or fiber drum with PE liner • Handling: Use PPE (nitrile gloves, safety goggles, lab coat). Avoid dust inhalation. Work in well-ventilated area or fume hood • Humidity: Protect from moisture — product is hygroscopic • Shelf Life: 24 months from manufacture date at room temperature • Transportation: Not classified as dangerous goods for transport (non-flammable, non-explosive) • Packaging Options: 25 g / 100 g / 500 g HDPE bottles; 1 kg / 5 kg / 25 kg fiber drums; custom sizes available • Labeling: GHS hazard pictogram (exclamation mark); SDS and TDS included |
| Compliance & Safety | 8. What regulatory and safety information applies to Sodium Taurodeoxycholate? | Safety classification and regulatory status: • GHS Classification: GHS07 (Exclamation mark) — Warning • Hazard Statements: H315 (Skin irritation), H319 (Eye irritation), H335 (Respiratory irritation) • Precautionary Statements: P264 (Wash thoroughly after handling), P280 (Wear PPE), P302+P352 (Skin contact: wash with soap and water), P305+P351+P338 (Eye contact: rinse with water for several minutes), P337+P313 (If eye irritation persists: seek medical attention) • Hazard Codes: Xi (Irritant) • Risk Statements: R37 (Irritating to respiratory system) • Safety Statements: S24/25 (Avoid contact with skin and eyes) • WGK Germany: 3 (Water hazard class) • HS Code: 2924.29 (Cyclic amides) • EINECS: 214-652-0 • FDA UNII: 5PE424S83L • Storage Class: 11 — Combustible Solids • REACH / TSCA: Registered / Listed. Compliance documents available upon request. |
| Procurement | 9. What is the minimum order quantity (MOQ) and typical lead time for Sodium Taurodeoxycholate? | • Research Sample: 5–25 g available for qualification • Standard MOQ: 25 g (research pack); 1 kg (bulk drum) • Lead Time: 7–15 working days for standard orders • Bulk Orders (≥25 kg): 20–30 working days • Payment Terms: T/T (30% deposit + 70% before shipment), L/C at sight, or negotiable • Incoterms: FOB Shanghai / CIF / DDP / EXW • Shipping: Suitable for air freight (small quantities) or sea freight (bulk) • Storage Class: 11 — no special dangerous goods surcharge • Volume discounts available for contract and recurring orders |
